Journal article

Circulating Chemerin Is Elevated in Women with Preeclampsia

LA Bartho, M Kandel, SP Walker, CA Cluver, R Hastie, L Bergman, N Pritchard, P Cannon, TV Nguyen, GP Wong, TM Macdonald, E Keenan, NJ Hannan, S Tong, TJ Kaitu'U-Lino

Endocrinology United States | Published : 2023

DOI: 10.1210/endocr/bqad041

Abstract

Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia. Methods: Maternal plasma and placenta were collected from women with early-onset preeclampsia (<34 weeks), with preeclampsia and eclampsia, or before preeclampsia diagnosis (36 weeks). Human trophoblast stem cells were differentiated into syncytiotrophoblast or extravillous trophoblasts across 96ahours. Cells were cultured in 1% O2 (hypoxia) or 5% O2 (normoxia). Chemerin was measured by enzyme-linked immunosorbent assay (ELISA) and RARRES2 (gene codi..

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University of Melbourne Researchers

Lucy Bartho Author

Susan Walker Author

Roxanne Hastie Author

Ping Cannon Author

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Keywords

Life Sciences & Biomedicine

32 Biomedical and Clinical Sciences

Perinatal Period - Conditions Originating in Perinatal Period

Reproductive Health and Childbirth

Maternal Morbidity and Mortality

Science & Technology

Endocrinology & Metabolism

3215 Reproductive Medicine

Contraception/reproduction

Pediatric Research Initiative

Maternal Health

Adipokine Chemerin